NFL odds Week 1: Lines for every game, picks
Are you ready for some football? We’re just one day from the first Sunday of the season!
Here is everything you need to know about the NFL odds for Week 1 — the point spread, moneyline, total over/under for every game and picks by FOX Sports betting analyst Jason McIntyre (with all NFL odds via FOX Bet).
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The defending Super Bowl champion Los Angeles Rams and 2021 Offensive Player of the Year, wide receiver Cooper Kupp, opened the season by taking an L to quarterback Josh Allen and the Super Bowl favorites, the Buffalo Bills.
Tom Brady and the Tampa Bay Buccaneers finish off this week’s slate of games Sunday, Sept. 11, by playing at the Dallas Cowboys. This powerhouse matchup should be a fun one to watch and gamble on.
Week 1 wraps up with the Denver Broncos and new quarterback Russell Wilson traveling to Seattle to take on Wilson’s former team, the Seahawks, on Monday Night Football on Sept. 12.
Opening weekend also got much juicier with the Cleveland Browns trading quarterback Baker Mayfield, the No. 1 pick in 2018, to the Carolina Panthers.
Guess who plays each other in Week 1 in Charlotte, N.C.?
Here are the updated Week 1 lines for every game (via FOX Bet):
WEEK 1 GAMES * odds updated as of 9/7/2022
Buffalo Bills @ Los Angeles Rams (8:20 p.m. ET Thursday, NBC)
Point spread: Bills -2 (Bills favored to win by more than 2 points, otherwise Rams cover)
Moneyline: Bills -138 favorites to win (bet $10 to win $17.25 total); Rams +115 underdogs to win (bet $10 to win $21.50 total)
Total scoring over/under: 52 points scored by both teams combined
New Orleans Saints @ Atlanta Falcons (1 p.m. ET Sunday, FOX)
Point spread: Saints -5.5 (Saints favored to win by more than 5.5 points, otherwise Falcons cover)
Moneyline: Saints -250 favorites to win (bet $10 to win $14 total); Falcons +200 underdogs to win (bet $10 to win $30 total)
Total scoring over/under: 42 points scored by both teams combined
San Francisco 49ers @ Chicago Bears (1 p.m. ET Sunday, FOX)
Point spread: 49ers -7 (49ers favored to win by more than 7 points, otherwise Bears cover)
Moneyline: 49ers -333 favorites to win (bet $10 to win $13 total); Bears +260 underdogs to win (bet $10 to win $36 total)
Total scoring over/under: 40.5 points scored by both teams combined
Pittsburgh Steelers @ Cincinnati Bengals (1 p.m. ET Sunday, FOX)
Point spread: Bengals -6.5 (Bengals favored to win by more than 6.5 points, otherwise Steelers cover)
Moneyline: Bengals -286 favorites to win (bet $10 to win $13.50 total); Steelers +225 underdogs to win (bet $10 to win $32.50 total)
Total scoring over/under: 44.5 points scored by both teams combined
FOX Bet’s Jason McIntyre: “Mike Tomlin as an underdog in a division game? Take my money. The Bengals will be the most overvalued team in the market next season. Yes, they have an elite QB/WR combo in Joe Burrow and Ja’Marr Chase, but let’s also remember this team faced the third-easiest schedule in the NFL last season.
“The Bengals will now face the seventh-most difficult schedule when looking at the opponent’s season win totals. Bengals fans can earmuff the rest; everyone else, listen closely. Cincinnati held on to beat the Raiders when they failed inside the 10-yard line on fourth down. The Bengals beat the Titans on a walk-off field goal and then beat the Chiefs in overtime despite KC getting the ball first. If they don’t win all three of those games, Pittsburgh is probably closer to +3 or +3.5.
“This line is inflated. Give me the extra points.”
PICK: Steelers (+6.5) to lose by fewer than 6.5 points (or win outright)
Philadelphia Eagles @ Detroit Lions (1 p.m. ET Sunday, FOX)
Point spread: Eagles -4 (Eagles favored to win by more than 4 points, otherwise Lions cover)
Moneyline: Eagles -213 favorites to win (bet $10 to win $14.69 total); Lions +175 underdogs to win (bet $10 to win $27.50 total)
Total scoring over/under: 49 points scored by both teams combined
New England Patriots @ Miami Dolphins (1 p.m. ET Sunday, CBS)
Point spread: Dolphins -3.5 (Dolphins favored to win by more than 3.5 points, otherwise Patriots cover)
Moneyline: Dolphins -182 favorites to win (bet $10 to win $15.49 total); Patriots +150 underdogs to win (bet $10 to win $25 total)
Total scoring over/under: 46 points scored by both teams combined
Baltimore Ravens @ New York Jets (1 p.m. ET Sunday, CBS)
Point spread: Ravens -7.5 (Ravens favored to win by more than 7.5 points, otherwise Jets cover)
Moneyline: Ravens -345 favorites to win (bet $10 to win $12.90 total); Jets +275 underdogs to win (bet $10 to win $37.50 total)
Total scoring over/under: 44.5 points scored by both teams combined
Jacksonville Jaguars @ Washington Commanders (1 p.m. ET Sunday, CBS)
Point spread: Commanders -2.5 (Commanders favored to win by more than 2.5 points, otherwise Jaguars cover)
Moneyline: Commanders -143 favorites to win (bet $10 to win $16.99 total); Jaguars +120 underdogs to win (bet $10 to win $22 total)
Total scoring over/under: 44 points scored by both teams combined
Cleveland Browns @ Carolina Panthers (1 p.m. ET Sunday, CBS)
Point spread: Panthers -1.5 (Panthers favored to win by more than 1.5 points, otherwise Browns cover)
Moneyline: Panthers -125 favorites to win (bet $10 to win $18 total); Browns +105 underdogs to win (bet $10 to win $20.50 total)
Total scoring over/under: 42 points scored by both teams combined
Indianapolis Colts @ Houston Texans (1 p.m. ET Sunday, CBS)
Point spread: Colts -7 (Colts favored to win by more than 7 points, otherwise Texans cover)
Moneyline: Colts -345 favorites to win (bet $10 to win $12.90 total); Texans +275 underdogs to win (bet $10 to win $37.50 total)
Total scoring over/under: 45.5 points scored by both teams combined
New York Giants @ Tennessee Titans (4:25 p.m. ET Sunday, FOX)
Point spread: Titans -5.5 (Titans favored to win by more than 5.5 points, otherwise Giants cover)
Moneyline: Titans -278 favorites to win (bet $10 to win $13.60 total); Giants +200 underdogs to win (bet $10 to win $30 total)
Total scoring over/under: 43.5 points scored by both teams combined
McIntyre: “I’m not a trend bettor, but one worth looking at in Week 1: Teams that didn’t make the playoffs last season against teams that did. Like it or not, the prior year’s playoff team tends to be overvalued in the market.
“When it comes to this matchup, the Titans were the No. 1 seed in the AFC last year. On the flip side, the Giants were one of the league’s biggest dumpster fires, and they fired their coach.
“I like New York’s new coach, Brian Daboll, and think he will be a tremendous value add to struggling QB Daniel Jones. The Giants will be undervalued with a full arsenal of healthy weapons — like Saquon Barkley and Kenny Golladay — in September.
“Getting nearly a touchdown in this spot is too good to pass up.”
PICK: Giants (+6.5 at FOX Bet at time of pick) to lose by fewer than 6.5 points (or win outright)
Green Bay Packers @ Minnesota Vikings (4:25 p.m. ET Sunday, FOX)
Point spread: Packers -2 (Packers favored to win by more than 2 points, otherwise Vikings cover)
Moneyline: Packers -133 favorites to win (bet $10 to win $17.52 total); Vikings +110 underdogs to win (bet $10 to win $21 total)
Total scoring over/under: 47 points scored by both teams combined
Kansas City Chiefs @ Arizona Cardinals (4:25 p.m. ET Sunday, CBS)
Point spread: Chiefs -6 (Chiefs favored to win by more than 6 points, otherwise Cardinals cover)
Moneyline: Chiefs -278 favorites to win (bet $10 to win $13.60 total); Cardinals +200 underdogs to win (bet $10 to win $30 total)
Total scoring over/under: 53.5 points scored by both teams combined
Las Vegas Raiders @ Los Angeles Chargers (4:25 p.m. ET Sunday, CBS)
Point spread: Chargers -3.5 (Chargers favored to win by more than 3.5 points, otherwise Raiders cover)
Moneyline: Chargers -182 favorites to win (bet $10 to win $15.49 total); Raiders +150 underdogs to win (bet $10 to win $25 total)
Total scoring over/under: 52 points scored by both teams combined
Tampa Bay Buccaneers @ Dallas Cowboys (8:20 p.m. ET Sunday, NBC)
Point spread: Buccaneers -2.5 (Buccaneers favored to win by more than 2.5 points, otherwise Cowboys cover)
Moneyline: Buccaneers -143 favorites to win (bet $10 to win $16.99 total); Cowboys +120 underdogs to win (bet $10 to win $22 total)
Total scoring over/under: 51 points scored by both teams combined
Denver Broncos @ Seattle Seahawks (8:15 p.m. ET Monday, ABC/ESPN)
Point spread: Broncos -6.5 (Broncos favored to win by more than 6.5 points, otherwise Seahawks cover)
Moneyline: Broncos -286 favorites to win (bet $10 to win $13.50 total); Seahawks +225 underdogs to win (bet $10 to win $32.50 total)
Total scoring over/under: 44.5 points scored by both teams combined
If you are betting on this week’s NFL slate, be sure to check out these posts below because we have you covered from every possible angle!
— Warren Sharp gives you his sharpest betting edges for Week 1
— Our Insider Patrick Everson breaks down all the hot, big–money chatter from Las Vegas
— Geoff Schwartz’s best wagers
— Jason McIntyre’s favorite bets
— Sammy P’s sharp college football and NFL wagers
— Our experts’ Super Bowl picks
Looking for even more NFL content? Head over to the NFL section on the FOX Sports app and website for all the latest news, and make sure to favorite the NFL and your favorite team — or teams! — while you’re there.
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